There's also evidence that PQQ can prevent glutamate-induced
neurotoxicity in brain cells in culture, helping to quell the storm of chemical stresses that such "excitotoxicity" produces.
The evaluation of
neurotoxicity can be achieved by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole) assay which is widely used in cytotoxicity studies.
They concluded that combination therapy is useful in local control of the newly diagnosed or relapsed cases without significant
neurotoxicity.11
The paper on
neurotoxicity was published online in Cancer Discovery; the one on cytokine release syndrome appeared online in the journal Blood.
High-dose cytarabine
neurotoxicity: MR findings during the acute phase.
Symptoms of
neurotoxicity typically begin within one to three days of starting the medication [6].
Kalayci et al., "Contrast-induced
neurotoxicity after coronary angiography," Herz, vol.
So far, several mechanisms of the cisplatin-induced
neurotoxicity have been proposed.
In Groups PX, GDX, and PX + GDX, cell apoptosis was observed and the number of apoptotic cells was significantly higher than that of Group A, indicating that PX or GDX could induce a significant increase of apoptosis in the OB, which means that apoptosis is involved in
neurotoxicity induced by PX and GDX.
Associated hazards include: acute toxicity (acute lethality at high concentrations only), blood toxicity, immunotoxicity, cardiovascular toxicity, liver toxicity, kidney toxicity, reproductive toxicity, developmental toxicity, and
neurotoxicity.