necrolytic migratory erythema

nec·ro·lyt·ic mi·gra·to·ry er·y·the·ma

an erythematous, scaling, and sometimes bullous erosive dermatitis occurring irregularly in plaques chiefly on the lower trunk, buttocks, perineum, and thighs; associated with weight loss, anemia, stomatitis, and elevation of plasma glucagon in islet cell tumor (glucagonoma) of the pancreas.
See also: glucagonoma syndrome.

Farlex Partner Medical Dictionary © Farlex 2012

necrolytic migratory erythema

A dermopathy associated with glucagonoma syndrome, which is characterised by waxing and waning erythematous patches that blister centrally, erode, then crust over and heal with hyperpigmentation in 10-day cycles. The lesions are often annular. They become confluent in severely affected areas. While no site is immune, NME is most common on the perineum, buttocks, groin, lower abdomen, and lower extremities, and other areas of pressure and friction.

Clinical findings
Pain, pruritus, atrophic glossitis, cheilosis, splitting of nails, buccal mucositis, dyspareunia; serum levels of glucagon do not correlate well with clinical disease.

Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

necrolytic migratory erythema

Dermatology A plaque dermatopathy seen on the lower trunk, buttocks, perineum, and thighs of Pts with a glucagonoma of the pancreas Clinical Erythematous, scaling, ± bullous, erosive lesions accompanied by weight loss, anemia, stomatitis Lab ↑ Glucagon. See Glucagonoma.

McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.