necrobiosis

[nek″ro-bi-o´sis]

the physiologic death of cells; a normal mechanism in the constant turnover of many cell populations. Called also bionecrosis. adj., adj necrobiot´ic.

necrobiosis lipoi´dica a dermatosis characterized by patchy degeneration of the elastic and connective tissue of the skin with degenerated collagen occurring in irregular patches, especially in the dermis, most often on the mid or lower shins; usually associated with diabetes.

nec·ro·bi·o·sis li·poi·d'i·ca

, necrobiosis lipoidica diabeticorum

a condition, in many cases associated with diabetes, in which one or more yellow, atrophic, shiny lesions develop on the legs (typically pretibial); characterized histologically by indistinct areas of necrosis in the cutis.

Farlex Partner Medical Dictionary © Farlex 2012

necrobiosis lipoidica

An inflammatory dermatosis that is most common in diabetics (75% of cases), usually on the legs. In 10% of patients, it precedes the onset of diabetes. It is less commonly associated with inflammatory bowel disease, rheumatoid arthritis, and thyroid disease.

necrobiosis lipoidica

Dermatology An inflammatory condition seen in 50-80% of DM, most often on the legs; in 10%, NL precedes onset of DM. See Non-insulin-dependent diabetes mellitus.

nec·ro·bi·o·sis li·poi·di·ca

, necrobiosis lipoidica diabeticorum (nek'rō-bī-ō'sis li-poyd'i-kă, dī-ă-bet'i-kōr'ŭm)

A condition often associated with diabetes, in which one or more yellow, atrophic lesions develop on the legs.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

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References in periodicals archive

Necrobiosis lipoidica diabeticorum treated with chioroquine.

Necrobiosis lipoidica and diabetic control revisited.

Successful treatment of chronic ulcerated necrobiosis lipoidica with 0.1% topical tacrolimus ointment.

Unsightly rash on shin: what started as a few small red spots was now an 8 x 6 cm well-demarcated red-brown plaque on the patient's shin. Was it linked to her diabetes?

* Necrobiosis lipoidica classically presents as annular violaceous plaques on the anterior legs, but may appear on the arms, hands, feet, or scalp.

Confluent annular lesion on the dorsum of the hand

Cutaneous manifestations such as diabetic dermopathy, necrobiosis lipoidica diabeticorum, syndromes of limited joint mobility are extremely important to the clinician as they are indicators of underlying chronic degenerative complications such as retinopathy, neuropathy and nephropathy and hence an "alarm bell to alert the physician".

Spectrum of cutaneous manifestations in diabetes mellitus and their association with duration of diabetes mellitus: An observational study in a tertiary care hospital of South India

Most frequently observed skin disease was bacterial infections (26%), followed by fungal infections (22%), acanthosis nigricans (20%), diabetic foot (16%), nail changes (16%), acrochordons (10%), diabetic dermopathy (9%), necrobiosis lipoidica (9%), viral infections (8%) pruritus (8%) and xanthelasma (8%).

Various common and rare skin disorders associated with diabetes include diabetic dermopathy, necrobiosis lipoidica, diabetic bullae, diabetic thick skin, yellow skin, acanthosis nigricans, eruptive xanthomas, disseminated granuloma annulare, scleredema, yellow nails, skin tags, diabetic rubeosis, vitiligo and lichen planus.

Other diseases seen with a lesser frequency in the descending order included: acrochordons, diabetic dermopathy, necrobiosis lipoidica, viral infections, pruritus and xanthelasma(Table 1).

Cutaneous manifestations of diabetes mellitus type 2: prevalence and association with glycemic control

A spectrum including pretibial pigmented patches and necrobiosis lipoidica diabeticorum.

Incidence of diabetic dermopathy