Further, we recently observed intense glomerular expression of human
myxovirus resistance protein 1, a type-I-interferon- (IFN-) dependent transcript, in biopsy specimens from patients with lupus nephritis, whereas negative staining occurred in specimens from patients with IgA nephropathy or purpura nephritis.
Other genes reported to be associated with AA include the
myxovirus resistance 1 (MX1) gene on chromosome 21q22.3 (Tazi-Ahnini et al., 2000) , autoimmune regulator (AIRE) gene on chromosome 21q22.3 (Buzi et al., 2003; Collins et al., 2006; Pforr et al., 2006), MHC class I polypeptide-related sequence A (MICA) gene on chromosome 6p21.3 (Barahmani et al., 2006), protein tyrosine phosphatase , non-receptor type 22 (PTNP22) gene on chromosome 1p13.3-p13.1 (Kemp et al., 2006), IL-1 receptor antagonists (IL1RN, IL1F5) genes on chromosome 2q14.2 (Tazi-Ahnini et al., 2002), macrophage migration inhibitory factor (MIF) gene on chromosome 22q11.23 (Shimizu et al., 2005),
Dentre os ISGs que aumentam sua expressao durante o inicio da gestacao em resposta ao IFNT, estao o 2',5' oligoadenilato sintetase (OAS; MIRANDO et al., 1991; SCHMITT et al., 1993; JOHNSON et al., 2001), o gene de resistencia ao
myxovirus 1 (MX1; (OTT et al., 1998) e o gene estimulado pelo interferon 15 (ISG15; NAIVAR et al., 1995; AUSTIN et al., 1996; JOHNSON et al., 1999).