(17,26-28) Focal high-grade sarcomas, with features similar to
myxofibrosarcoma, have been reported in several cases, especially recurrences.
The morphologic features were those of an epithelioid
myxofibrosarcoma (MFS) of high grade.
Kaun et al., "Patellar tendon reconstruction using a free latissimus dorsi flap following resection of a prepatellar
myxofibrosarcoma: Case report," Journal of Reconstructive Microsurgery, vol.
Due to the vast range of histological appearance at the MFH diagnosed tumors, they were further subdivided into (1) storiform-pleomorphic, (2) myxoid (
myxofibrosarcoma), (3) giant cell, (4) inflammatory, and (5) angiomatoid [8].
Shinomiya et al., "Modified partial maxillary swing approach for
myxofibrosarcoma in pterygopalatine fossa," Head and Neck, vol.
Immunostain for S-100 protein and GNAS 1 mutations can distinguish myxoid liposarcoma and low-grade
myxofibrosarcoma from intramuscular myxomas, respectively [20,21].
DFML can be confused with other more clinically aggressive neoplasms, including myxoid liposarcoma (MLS), low-grade fibromyxoid sarcoma (LFMS), and
myxofibrosarcoma, especially the low-grade type, highlighting the importance of its recognition.
Soft-tissue sarcomas are tumors arising from extraskeletal connective tissues and from Schwann cells and include fibrosarcoma, liposarcoma, hemangiopericytoma, rhabdomyosarcoma, lymphangiosarcoma, malignant fibrous histiocytoma, leiomyosarcoma, myxosarcoma,
myxofibrosarcoma, mesenchymoma, spindle cell tumors, and malignant peripheral nerve sheath tumors (neurofibrosarcoma, Schwannoma).
Examples of patients with aggressive cancers, such as pancreatic cancer, grade IV glioblastoma, stage 3 serous carcinoma of the uterus, stage 4
myxofibrosarcoma, stage 4 invasive ductal carcinoma, chronic myelogenous leukemia, stage 4 colon cancer, and many others once diagnosed and treated for MSCIS, have resolution or stabilization of their cancers as evidenced at my clinic.
It was, according to the final biopsy result, "low-grade malignant peripheral nerve sheath tumor," a "Myxoid Malignant Fibrous Histiocytoma (
Myxofibrosarcoma) to be specific.