Clostridium
myonecrosis progresses rapidly, often presenting with sudden onset severe pain at the site of infection with a mean incubation period of less than 24 hours.
Based on the clinical history as well as labs and imaging findings, a diagnosis of diabetic
myonecrosis was made.
Key words: Clostridium sordellii, Clostridium perfringens, avian clostridiosis,
myonecrosis, enteritis, cytotoxins, avian, brown pelican, Pelecanus occidentalis
In our case, the diagnosis was delayed and our patient experienced
myonecrosis with resulting myoglobinuria that required intensive care monitoring and resuscitation but did not progress to acute tubular necrosis.
Rastogi et al., "Spontaneous diabetic
myonecrosis: report of four cases from a tertiary care institute," Endocrinology, Diabetes & Metabolism Case Reports, Article ID 150003, 2015.
In more progressed cases, MRI demonstrates intramuscular fluid collections which can represent abscesses or
myonecrosis [31].
CS causes infection through
myonecrosis and release of exotoxins.
They have contraction band necrosis with variable amounts of
myonecrosis; some cases also have interstitial inflammatory cells, such as neutrophils and lymphocytes [41, 49, 50].
perfringens strains produce a-toxin, a major extracellular toxin that has been shown to be essential for clostridial
myonecrosis (Awad et al.