mechlorethamine

A nitrogen mustard derivative which binds to DNA, crosslinking both strands to prevent its replication.

Global village
Mechlorethamine was first developed as a chemical weapon.

Oncology
A nitrogen mustard alkylating agent used for managing lymphomas; part of MOPP.

Adverse effects
Nausea, vomiting, marrow suppression, skin vesiculation at injection site.

mustine

Chlormethine, a drug used to treat some cases of HODGKIN'S DISEASE. It is very toxic and is liable to cause severe vomiting.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

References in periodicals archive

Long term follow up of topical mustine treatment for cutaneous langerhans cell histiocytosis.

Langerhans Cell Histiocytosis: A Clinicopathologic Review and Molecular Pathogenetic Update

Kasich, Solon Vice Mayor Edward Kraus and Jobs Ohio Managing Director David Mustine.

New R and D investment will strengthen Nestle's expertise in Frozen and Chilled foods

"Recycling saves energy, conserves our natural resources, and extends the life of a landfill, all while creating jobs," said David Mustine, Director of the Ohio DNR.

Ohio community grant program rewards recycling, trash reduction

(15,19) When treatment is necessary, a minimalist approach should be selected--one that includes a topical steroid, topical mustine (nitrogen mustard, an alkylating agent), and possibly steroid injections.

Langerhans' cell histiocytosis: current trends and the role of the head and neck surgeon

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