The researchers found that in the Leicester cohort, CTA was an independent prognostic factor after adjusting for Breslow thickness, age, sex, ulcer,
mitotic rate, and microsatellites (hazard ratio [HR], 1.87).
Tumours categorised as low grade have Ki-67 index of less than 3% and a
mitotic rate 20/10 HPF.
(1, 8) However, a subgroup of PMDM showing marked pleomorphism, decreased cell cohesion, atypical mitotic figures, and high
mitotic rate (>5 mitosis/10 high-power fields) seems to have a highly aggressive clinical course.
Most cases demonstrated minimal atypia and low
mitotic rate (0-1/10 high power field (hpf)), consistent with low-grade features.
Otorhinolaryngologic examination showed a 3.8 cm x 2.5 cm growth right pyriform sinus (PFS), biopsy from which revealed pleomorphic spindle cell tumor with large hyperchromatic nuclei, prominent nucleoli with frequent mitosis with a
mitotic rate of 4 per high-power-field arranged in intersecting fascicles.
The tumor was assigned a Breslow depth of 6.5mm and a
mitotic rate of 5/mm2.
* Dermal
mitotic rate is no longer used in staging T1 tumors, although it's still supposed to be included in pathology reports.
* Dermal
mitotic rate is no longer used in staging Tl tumors, although it's still supposed to be included in pathology reports.
found through multivariate analysis that
mitotic rate [greater than or equal to] 5, tumor size [greater than or equal to] 10 cm, and primary tumor location were independent factors for recurrence [21].
After Breslow thickness, both
mitotic rate and ulceration reporting are important for the surgical oncologist in treatment planning.
Minimal pleomorphism and a
mitotic rate of <2 mitotic figures/50 HPFs are identified.
In general, prognosis of GIST depends upon the size of the tumor and to the
mitotic rate: tumors > 10 cm or with a
mitotic rate of >5 per 50 HPF having higher risk of recurrence, metastatic spread, and a poorer prognosis.