micafungin

An echinocandin-type antifungal with better pharmacokinetics than amphotericin B and itraconazole.

Indications
Candida species infections: candidemia, acute disseminated candidiasis, Candida peritonitis and abscesses.

Metabolism
Via CYP3A4.

micafungin

An echinocandin antifungal drug active against both Candida and Aspergillus species of fungi. The drug function by inhibiting fungal wall synthesis, an action without relevance for mammalian cells, and is thus of low toxicity. It has been found effective in the management of candidaemia and invasive candidosis.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

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References in periodicals archive

Micafungin is also an effective treatment for candidaemia.7

Determination of minimum inhibitory concentrations of various antifungal agents in clinical isolates of Candida species

All patients were given micafungin as first-line therapy for an average duration of 22 days.

Management of Patients with Candida auris Fungemia at Community Hospital, Brooklyn, New York, USA, 2016-2018

The difficulty in following this recommendation is illustrated in a randomized trial of treatment of candidemia comparing micafungin with liposomal amphotericin B, (26) in which CVC removal at baseline (before treatment initiation) was required per protocol.

Time of catheter removal in candidemia and mortality

glabrata Isolates with Mutations in fks Genes," combines the results of several in vitro studies of ibrexafungerp against a total of 79 Candida glabrata strains with fks mutations showing that ibrexafungerp maintains potent activity against these echinocandin-resistant strains when compared to caspofungin and micafungin. In five independent studies, the in vitro susceptibility, determined by broth micro-dilution, of C.

Scynexis presents ibrexafungerp data at 2018 ESCMID/ASM conference

Paradoxical growth effects of the echinocandins caspofungin and micafungin. but not of anidulafungin.

Molecules and Mechanisms Underlying the Antimicrobial Activity of Escapin, an L-Amino Acid Oxidase from the Ink of Sea Hares

However, blood cultures grew Candida albicans, and micafungin was initiated.

Deaths associated with insertion of nasogastric tubes for enteral nutrition in the medical intensive care unit: Clinical and autopsy findings

The antifungal agents assayed were: amphotericin B (AMB), itraconazole (ITC), voriconazole (VRC), posaconazole (POS), fluconazole (FLU), caspofungin (CAS), micafungin (MFG), anidulafungin (AFG).

Phenotypic typing and epidemiological survey of antifungal resistance of Candida species detected in clinical samples of Italian patients in a 17 months' period

Se realizaron 4 busquedas en cada base de datos, utilizando los siguientes terminos MeSH: Echinocandin Candida resistant, Anidulafungin Candida resistance (or resistant), Caspofungin Candida resistance (or resistant), Micafungin Candida Resistance (or resistant).

Opciones terapeuticas frente a especies de Candida resistentes a las equinocandinas

Echinocandin (caspofungin, anidulafungin, micafungin) or fluconazole is recommended for empirical antifungal therapy.

Current Diagnosis and Treatment Approach to Sepsis/Sepsiste Guncel Tani ve Tedavi Yaklasimi

These include the polyene group that encompasses amphotericin B deoxycholate and its lipid formulations (liposomal amphotericin B, amphotericin B lipid complex, and amphotericin B cholesteryl sulfate complex); the nucleoside analogue flucytosine; the triazoles which include fluconazole and voriconazole; and the most recently developed echinocandin class, which includes caspofungin, micafungin, and anidulafungin.

The Role of Antifungals in Pediatric Critical Care Invasive Fungal Infections