Caption: FIGURE 2: Minimal soft tissue edema surrounding the left proximal tibial
metaphysis and diaphysis with corresponding mild enhancement suggestive of early acute osteomyelitis.
Clonally expanding Gremlin1+ cells were identified in growth plate and
metaphysis region and they lack adipocyte differentiation potential [71].
In addition, granulation is often limited owing to
metaphysis and is very slow to grow on diaphysis.
Here, we present a case of tuberculosis of the distal tibial
metaphysis which is a rare localization in infants aged younger than 1 year.
The physeal injury sustained is primarily a Salter-Harris type 1 fracture in which a transverse fracture through the physis separates the epiphysis from the
metaphysis. (4) A Salter-Harris 1 fracture occurs in 6% of Salter-Harris fractures.
Children are more susceptible to AHOM because their bones have a nutrient rich arterial supply to the
metaphysis (2,5,9).
At the
metaphysis of the radius, a site that is susceptible to wrist fracture during growth, moderate and combined MVPA were associated with bone strength, while at the cortical tibia only vigorous activity was associated with bone strength.
The total width of the inner layer of the diaphysis was decreased by 7.2% (p [less than or equal to] 0.05); the width of this layer in
metaphysis was decreased by 14.2% (p [less than or equal to] 0.05).
The main features of the disease are shortening of the proximal long bones, punctate calcifications in the
metaphysis and epiphysis of long bones and the thoracic and lumbar vertebrae, dysmorphic face, and severe growth retardation.
The regions of interest (ROI) included the trabecular bone of the
metaphysis (0.24-1.40 mm above the growth plate) and the cortical bone of the midshaft (1.19 mm in length spanning the midpoint between the condyles and femoral neck).
The right tibia was used to collect growth plate and
metaphysis bone samples that were frozen in liquid nitrogen and stored at -80[degrees]C until being used for RNA extraction and gene expression analysis.