Medical

matrix bias

matrix bias

Any deviation in values for a particular analyte which was introduced by a matrix effect. Matrix bias impacts on proficiency testing values and lab results in general.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
Our data suggest that dilution with distilled water led to poor commutability at a low level (6.0 ng/mL) between different measurement protocols, with a matrix bias of 20% to 66% (Table 4; Figure
Commutability of Reference Materials for [alpha]-Fetoprotein in Human Serum
A matrix effect or a matrix bias can be caused by differences in sample matrix between the reference material and the native clinical samples.
Why commutability matters
[6], we calculated a matrix bias correction factor.
A statistically significant difference indicates the presence of a matrix bias (i.e., noncommutability of the material).
By using the formula illustrated in Materials and Methods, one can calculate a "matrix bias correction factor" taking into account the different components of the calibration bias.
All matrix bias correction factors were calculated with the peer group means, but we tried also to calculate the factors by using single laboratory data of the same peer group.
The matrix-adjusted target values can be an acceptable compromise that allows the utilization of the lyophilized sera provided that two important limitations are adequately considered: (a) the matrix bias correction factor can be calculated only for well-defined analytical systems; (b) the serum pools used in generating the algebraic correction are the same as normal fresh serum specimens.
Creatinine measurement proficiency testing: assignment of matrix-adjusted I D GC-MS target values
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