malignant mixed Müllerian tumour

malignant mixed Müllerian tumour

A malignancy of the female genital tract (2–5% of corpus tumours, fallopian tubes, cervix, vagina and paramesonephric/Müllerian parts) affecting post-menopausal (median age 66) women, which is thought to arise in a carcinoma with sarcomatous transformation. The term carcinosarcoma (of uterus) is preferred by gynaecological pathologists.

Types
•  Carcinoma—serous, high-grade endometrioid, mucinous, clear cell, squamous, mixed.
•  Sarcoma—homologous (Leiomyo/fibrosarcom(1) or heterologous (cartilage/skeletal muscle).

Metastases are often purely carcinomatous, rarely purely sarcomatous.

Clinical findings
Vaginal bleeding.

Risk factors
Obesity, prior pelvic irradiation.

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