For macromolecular crystals (canavalin, thaumatin and lipase), hollow cores are observed in some cases (Kutnetsov, et al., 1999 and Land, et al., 1995) and not observed in other cases due to the small value of the elastic energy associated with the dislocation (e.g.
AFM studies of the nucleation and growth mechanisms of macromolecular crystals. Journal of Crystal Growth, 196: 489-502.