(9-16) In mice, Reishi has been found to promote the maturation and activation of immune system cells such as T cells, natural
killer cells, dendritic cells, and macrophages.
Porto et al., "Age-related changes in natural
killer cell receptors from childhood through old age," Human Immunology, vol.
Guethlein et al., "Donor selection for natural
killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia," Blood, vol.
Suzuki et al., "Genome-wide array-based comparative genomic hybridization of natural
killer cell lymphoma/leukemia: different genomic alteration patterns of aggressive NK-cell leukemia and extranodal NK/T-cell lymphoma, nasal type," Genes Chromosomes and Cancer, vol.
A human natural
killer cell subset provides an innate source of IL-22 for mucosal immunity.
Khakoo, "Natural
killer cells and hepatitis C: action and reaction," Gut, vol.
Altfeld, "CD107a as a functional marker for the identification of natural
killer cell activity," Journal of Immunological Methods, vol.
Natural
killer cell activity in very low birth weight infants.
The investigators assessed 57 women over 2 years and found that variations in natural
killer cell levels corresponded to changes in depression status and ratings on the 17-item Hamilton Depression Rating Scale.
There was also no significant change in the mean value of the number of natural
killer cells in both treatment periods (Table 2).
Association of depression, CD8+ T lymphocytes, and natural
killer cell activity: Implications for morbidity and mortality in human immunodeficiency virus disease.