One patient still requires
ketotifen therapy with concurrent diphenhydramine therapy to tolerate antibiotics, Dr.
Antiallergic action of betostatine besilate (TAU-284) in animal models: a comparison with
ketotifen. Pharmacology 57, 206-214.
Moreover, in vivo investigations with compound 48/80 and mast cell stabilizing agents including
ketotifen and sodium cromoglycate should be carried out by constituting animal models of migraine pain.
Pharmacological mast cell stabilization (
ketotifen) and tryptase and chymase inhibition (nafamostat and NK3201, resp.) decrease mucosal damage in TNBS colitis [37-40].
sodium cromoglycate, nedocromil sodium, pemirolast, and lodoxamide; (3) Dual acting agents - they have both antihistaminic and mast cell stabilizing properties, e.g., olopatadine,
ketotifen, azelastine, and epinastine; (4) Non-steroidal anti-inflammatory drugs, e.g., ketorolac, diclofenac, and flurbiprofen; (5) Corticosteroids, e.g., prednisolone, hydrocortisone, fluorometholone, loteprednol, and desonide.
Koopman et al., "The mast cell stabiliser
ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome," Gut, vol.
Gabapentin and
ketotifen are two drugs used for treating uremic patients.The aim of this study was to compare gabapentin and
ketotifen in treatment of uremic pruritus in hemodialysis patients.
There are no human eye data for bepotastine (Bepreve),
ketotifen (Alaway), and olopatadine (Pataday, Patanol).
Among topical antihistamines and anti-allergy drugs,
ketotifen, olopatadine and epinastine are category C drugs; sodium cromoglycate and emedastine are in category B.
For ocular symptoms of allergic rhinitis, patients may benefit from available O-T-C ophthalmic antihistamines, or
ketotifen fumarate, an ophthalmic antihistamine/mast cell stabilizer.
Ketotifen fumarate (Zaditor) is an available over-the-counter treatment option, but olopatadine HC1 (Pataday) is the most popular prescription written by pediatricians.