Wilson, "Effect of prophylactic and therapeutic mitomycin C on corneal apoptosis, cellular proliferation, haze, and long-term
keratocyte density in rabbits," Journal of Refractive Surgery, vol.
Guthoff, "The
keratocyte network of human cornea: A three-dimensional study using confocal laser scanning fluorescence microscopy," Cornea, Vol.
However, if the increase in the level of the ones in the form of lactate is more than the discharge, it gathers in the stroma by creating an osmotic load and corneal edema happens in there.14 The reason for 2% thinning in the cornea after edema has disappeared is the worsening and potential
keratocyte death.
These include increased inflammatory mediators and loss of
keratocytes, abnormal enzyme function and loss of collagen, anomalous
keratocyte function and altered fibrillogenesis, altered proteoglycan production, reduced tensile strength, collagen slippage in cone, and cone formation by biomechanically coupled curvature transfer.
Keratocyte apoptosis and failure of corneal allografts.
Histopathologic features include changes in corneal collagen structure and organization, alterations of the extracellular matrix, and
keratocyte apoptosis and necrosis involving the anterior stroma and Bowman's layer, iron deposition in the epithelial basement membrane, and breaks in the Bowman lamina, which partially explain the biomechanical corneal weakening typical of the disease [7].
Modulation of acute inflammation and
keratocyte death by suturing, blood, and amniotic membrane in PRK.
The increased collagen fiber diameter [8],
keratocyte apoptosis, and subsequent transformation into myofibroblasts [9] are the reported corneal changes on transmission electron microscopy that interpret the reduction in corneal transparency noted post-CXL.
Because anatomical regularity of the collagen fibrils, integrity of connective tissue, and balanced
keratocyte components play an important role in corneal clarity, it can be hypothesized that corneal densitometry may be altered in the presence of a systemic inflammatory disease, even in the absence of any corneal haze or scar.