Medical

isotype switch

the process whereby the constant region gene of an antibody heavy chain is replaced with the constant region gene of another isotype, although the antigen-binding portion of the molecule is unchanged.

Farlex Partner Medical Dictionary © Farlex 2012

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References in periodicals archive

In mouse models, Tfh cells are a central source of IL-21 in germinal centers of secondary lymphoid organs, providing cognate help to B cells in the germinal center dynamic microenvironment, acting specially on naive B cells to induce isotype switch to IgG and IgA (68).

Follicular helper T cell in immunity and autoimmunity

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