intermediate lymphocytic lymphoma

mantle cell lymphoma

An uncommon low-to-intermediate-grade non-Hodgkin lymphoma (NHL), which is a malignancy of naive B cells. It comprises ± 6% of NHL cases in the US, slightly higher in Europe. It is hard to treat and harder to cure. It is more common in men ≥ age 55.
 
Clinical findings
Massive splenomegaly, generalised lymphadenopathy, 1/3 present with “B” symptoms—i.e., fever, weight loss, night sweats.

Sites
Nodes, spleen, bone marrow, Waldeyer's ring, GI (lymphomatous polyposis), gallbladder. 

DiffDx
• Small lymphocytic lymphoma/CLL
• MALT lymphoma
• Follicular lymphoma

Prognosis MCLs are often aggressive and involve the spleen, liver, bone marrow; they are regarded as incurable. Median 2- to 5-year survival. Cases with mutations in the immunoglobulin gene have better prognosis—40% achieve complete remission with chemotherapy.

Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

intermediate lymphocytic lymphoma

Mantle-zone lymphoma Hematology An indolent B-cell lymphoma of older adults, related to small cell follicular lymphoma, composed of cells similar to those of WD lymphocytic lymphoma. See Lymphoma.

McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.