It is known that patients who have received treatment with
insulin detemir, in particular, should be given two doses daily to achieve fasting glycemic control (4).
Once-daily initiation of basal insulin as add-on to metformin: a 26-week, randomized, treat-to-target trial comparing
insulin detemir with insulin glargine in patients with type 2 diabetes.
Spending on drugs used by patients with diabetes, 2015 Billions of dollars Insulin glargine 1 Rosuvastatin 2 Atorvastatin 4 Insulin aspart 7 Sitagliptin 8 Insulin isophane (NPH) 9 Pregabalin 10 Gabapentin 11
Insulin detemir 12 Metformin 14 Insulin lispro 16 Metformin-sitagliptin 20 The number in each bar represents the drug's place in the top 20 for spending for all drugs.
Ribel et al., "The mechanism of protraction of
insulin detemir, a long-acting, acylated analog of human insulin,"
Shehadeh et al,5 through an open label, prospective, controlled multicenter cluster non-inferiority randomized study, assessed the use of
insulin detemir and BIAsp 30 during Ramadan.
Insulin analogues (
insulin detemir and insulin aspart) versus traditional human insulins (NPH insulin and regular human insulin) in basal-bolus therapy for patients with type 1 diabetes.
[160] reported that insulin replacement therapy could be associated with increased EAT mass, as shown by their open label interventional study comparing
insulin detemir with insulin glargine.
* The major global barrier for the T1Dmarket will be the biosimilar erosion of the leading insulin brands for T1D treatment, such as Lantus (insulin glargine), Levemir (
insulin detemir), Humalog (insulin lispro), and NovoLog (insulin aspart).
Researchers randomly assigned 60 people with mild cognitive impairment (MCI) or mild to moderate Alzheimer's disease to get either a placebo or one of two intranasal doses (20 or 40 IU a day) of a long-acting type of insulin (
insulin detemir).
Similarly, Novo Nordisk last summer debuted the prefilled insulin delivery device Levemir FlexTouch (
insulin detemir [rDNA origin] injection) in the United States.
Those who received larger doses of the
insulin detemir drug showed more improvement than those who had less or a placebo.
Comparison of
Insulin Detemir and Insulin Glargine in Subjects with Type 1 Diabetes Using Intensive Insulin Therapy.