Infective endocarditis in adults: Diagnosis, antimicrobial therapy, and management of complications: A scientific statement for healthcare professionals from the American Heart Association.
Demographic and clinical characteristics of patients (N=68) with
infective endocarditis due to intravenous nyaope use Age (years), mean (SD) 25.8 (4.5) Male gender, % 97.1 Level of education, mean Grade 10 Employed None Duration of drug use (months), median (IQR) 48 (24-72) NYHA functional class (I/II--III/IV), % 12.6/80.2/7.3 Systolic blood pressure (mmHg), mean (SD) 113.9 (14.8) Diastolic blood pressure (mmHg), mean (SD) 68.7 (11.2) Pulse rate (bpm), mean (SD) 104.3 (22.0) SD = standard deviation; IQR = interquartile range; NYHA = New York Heart Association.
Serban, "Recurrent
infective endocarditis of the native aortic valve due to ESBL producing Escherichia coli (E coli) after therapeutic ERCP," Journal of Gastrointestinal and Liver Diseases, vol.
Patients with a low clinical probability of
infective endocarditis should not have an echocardiogram performed because it has low positive predictive value and low diagnostic yield, the authors concluded.
Rapid diagnosis, effective treatment and prompt recognition of complications are essential for a good outcome of
infective endocarditis, which carries a high morbidity and mortality rate.
Erwin et al., "Global and regional burden of
infective endocarditis, 1990-2010: a systematic review of the literature," Global Heart, vol.
Secondary involvement of the anterior mitral leaflet may appear in patients with
infective endocarditis affecting the aortic valve because of the intimate anatomic relationship between the two valves.
Although HACEK organisms are documented to comprise up to 3% of all
infective endocarditis cases, 60% of individuals with HACEK bacteremia are found to have endocarditis as well.
AMSTERDAM -- Data presented at the annual congress of the European Society of Clinical Microbiology and Infectious Diseases suggest that Propionibacterium acnes may be responsible for many more cases of
infective endocarditis than is now believed.
Neurologic complications occur in 20%-40% of patients with
infective endocarditis. Mycotic aneurysms are one example of these complications, and although rare, they can confound a patient's recovery and increase morbidity and mortality.