Another study reported on 30 patients with stage II or III cervical cancer randomized to receive either
hyperfractionation (15 Patients) or conventional fractionation (15 Patients).
weeks, and RT fractionation is planned as
hyperfractionation. Gefitinib continued as adjuvant chemotherapy for 2 years.
A single institutional phase III trial of preoperative chemotherapy with
hyperfractionation radiotherapy plus surgery versus surgery alone for resectable esophageal squamous cell carcinoma.
(18,35,36) Clinically, radiation fractionation strategies have attempted to overcome tumor repopulation via
hyperfractionation, in which smaller doses are given more frequently, or via accelerated fractionation protocols, in which the dosing schedule occurs at shorter intervals to achieve the total dose more quickly.
This technique is the basis of radiotherapeutic techniques, such as
hyperfractionation, which seeks to control tumors (with responses similar to the acute response tissues) without damaging the adjacent differentiated tissues.
Grigsby, "Anaplastic thyroid carcinoma: comparison of conventional radiotherapy and
hyperfractionation chemoradiotherapy in two groups," American Journal of Clinical Oncology, vol.
An additional radiation therapy method is
hyperfractionation, which involves a higher dose of radiation as compared with conventional fractionation.
Hyperfractionation.
Hyperfractionation typically refers to twice-daily delivery.
In
hyperfractionation, the total dose of radiation remains approximately the same as in standard therapy, but it is given in smaller doses 2 or 3 times per day.
Hyperfractionation is the use of large fractions smaller than standard dose per fraction per day.
Analysis of data from various
hyperfractionation studies reveals significant improvement in the tumor and overall survival.