Their special features are perivascular
hyalinization, dominant stroma, and trabecular arrangement.
Recently, in a histopathological, biochemical and immunological study carried out on the gastrocnemius muscle and myotendinous junction of DGR animals, similar alterations to those observed in humans affected by muscular dystrophy were observed, such as fibrosis,
hyalinization, hypertrophy, necrosis, calcification and regeneration.
Magnified picture of part of (a) shows
hyalinization (b) and bone formation (c).
Subepithelial fibrous tissue revealed a zone of
hyalinization (Fig.
It is also associated with irregular thinning and
hyalinization of the cartilage adjacent to the cavity.
There was increased
hyalinization of the papillary dermis with newly deposited collagen fibers.
On subsequent Scalpel Biopsy, lesion was confirmed as lymph node with extensive
hyalinization and calcification i.e., Castleman's Disease.
The gross pathological features include a well-circumscribed lobulated or multinodular encapsulated mass with varying degrees of
hyalinization. On microscopy, the cellular infiltrate is constituted by macrophage-like mononuclear cells, epithelioid histiocyte-like cells, osteoclast-like giant cells, and xanthomatous cells.
Pathologic samples (Figure 3) showed polygonal pleomorphic poorly differentiated myxoid cytoplasm with apoptosis and fibrous bands interwoven between tumor cells with extensive
hyalinization positive for keratin, vimentin and p63.
Perivascular
hyalinization was seen relative to the vascular spaces (figure 1, B).
A long term study on primates showed that it altered the blood glucose levels as well as the histology of pancreas showing
hyalinization of pancreatic islets of langerhans8.
Rarely, the tumor may show areas of
hyalinization, calcification, or myxoid change.