holoenzyme

[hol″o-en´zīm]

the active compound formed by combination of a coenzyme and an apoenzyme.

hol·o·en·zyme

(hol'ō-en'zīm),

A complete enzyme, that is, apoenzyme plus coenzyme, cofactor, metal ion, and/or prosthetic group.

Farlex Partner Medical Dictionary © Farlex 2012

holoenzyme

(hŏl′ō-ĕn′zīm′, hō′lō-)

An active, complex enzyme consisting of an apoenzyme and a coenzyme.

hol·o·en·zyme

(hol'ō-en'zīm)

A complete enzyme, i.e., apoenzyme plus coenzyme, cofactor, metal ion, and/or prosthetic group.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

holoenzyme

A complete enzyme that includes its prosthetic coenzyme. An enzyme without its coenzyme is called an apoenzyme.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

holoenzyme

an entire conjugated enzyme consisting of a protein component (an apoenzyme) and a nonprotein component (a coenzyme or an activator).

Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

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References in periodicals archive

Through analysis and observations of these seven native states, the authors conclude that these seven states are on the pathway of substrate processing by the holoenzyme.

A Landmark Research on Human Proteasome for Pathogenesis of Multiple Myeloma and Neurodegenerative Diseases

For this, we purified recombinant Med6p having ts-2 mutation or internal deletion mutations and examined their capabilities in restoring the transcriptional defects of Pol II holoenzyme caused by med6 ts-2 mutation [20].

Postrecruitment Function of Yeast Med6 Protein during the Transcriptional Activation by Mediator Complex

Conceptually, one might expect that a similar number of activated [T.sup.287] autophosphorylated subunits ([T.sup.286] in alpha isoform) would produce similar levels of substrate phosphorylation within the PSD regardless of whether the catalytic subunits are within a holoenzyme or monomeric.

Activation State-Dependent Substrate Gating in [Ca.sup.2+]/Calmodulin-Dependent Protein Kinase II

There was a non-significant change observed in holoenzyme activity after 3.5hrs (acute) treatment in contrast there was significant decrease by 32% (pless than 0.01) after 7 days treatment.

Diclofenac Sodium Inhibits Hepatic Tryptophan 2,3-Dioxygenase but Augments Brain Indoleamine 2,3-Dioxygenase Activities in Rats

An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications.

Insights into the management of diabetic neuropathy

Romanowski et al., "MCM proteins are associated with RNA polymerase II holoenzyme," Molecular and Cellular Biology, vol.

MCM paradox: abundance of eukaryotic replicative helicases and genomic integrity

More recent work indicates that the induction of cyclin D-CDK complexes results in the redistribution of CDK inhibitor p27Kip1 from cyclin E-CDK2 complexes to cyclin D-CDK4y6 complexes, thereby triggering the kinase activity of cyclin E-CDK2 holoenzyme [13].

Effects of thapsigargin on the proliferation and survival of human rheumatoid arthritis synovial cells