Under the action of the control formulations without herbs,
hepatotoxin after injection showed a significant decrease in IAA and increase in the concentration of MDA--the product of oxidative degradation of fatty acids, and the reduction of antioxidant activity was greater in the control number 2, the formulation of which included the thickening agent carrageenan.
Several genera of cyanobacteria, such as Microcystis, Anabaena, and Oscillatoria produce a family of microcystins of at least 50 tumor-promoting
hepatotoxins [6, 10, 21].
IRIS, HIV-related opportunistic infections, and other
hepatotoxins (e.g.
It is evident that several phytoconstituents have the ability to induce microsomal enzymes either by accelerating the excretion of
hepatotoxin or by inhibition of lipid peroxidation induced by it (10).A good number of naturally occurring compounds have been shown to protect liver and other organ from damage(11) .Phytoconstituents like flavonoids(12), triterpenes(13), saponins(14) and alkaloids (15) are known to possess hepatoprotective activities.
The control group received 0.1 mL of vehicle (30% DMSO) and toxicant group received 0.01 mL of respective test solutions (100, 200 and 500 [micro]g/mL of extracts/ fractions dissolved in 30% DMSO) followed by 0.1 mL of silymarine solution (100 [micro]g/mL) followed by respective
hepatotoxin. The contents of all the tubes were made up to 1 mL with HEPES buffer I.
Some strains have the capacity to produce microcystin, a
hepatotoxin which, when present in large concentrations, can cause mortality of the animals inhabiting or using the body of water (Krienitz et al, 2003; Ballot et al., 2004).
Mechanisms offormation ofprotein-arylating intermediates from amodiaquine, a myelotoxin and
hepatotoxin in man.
Recently a case was decided over the denial of employment to an individual with possible liver damage for a job in which he might be exposed to
hepatotoxin: Echazabal v.
Although D-GaIN has been known as a
hepatotoxin causing necrosis, it has also been reported to induce apoptosis in the liver of rats.
Figures 1 represent only results derived from the three methods for the detection of cyclic peptide
hepatotoxin genes by using HEPF and HEPR primers was developed to identify potentially microcystin or nodularin in two genus of cyanobacteria.