heat-shock proteins

A range of peptides that are well conserved throughout a wide range of organisms and are produced by the body in response to various stressors. They are found in high concentration in plaques of ATHEROSCLEROSIS and levels of heat-shock proteins in people who have suffered strokes and heart attacks, and women with breast cancer, are higher than in controls. Antibodies against bacterial HSP can cross-react with human HSP60 causing cytotoxic damage to endothelial cells stressed by FREE RADICALS or infection. Heat-shock proteins are also associated with oral ulcers and Behçet's disease. They are found in a variety of bacteria.

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

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References in periodicals archive

The comprehensive study of heat-shock proteins is of great importance to both livestock and aquaculture.

Hsp70 function and polymorphism, its implications for mollusk aquaculture: a review

Molecular chaperone functions of heat-shock proteins. Annu.

Molecular Characterization of Heat Shock Protein 70-1 Gene of Capra aegagrus blythi

Mycobacterial heat-shock proteins as carrier molecules.

The Distinct Role of Small Heat Shock Protein 20 on HCV NS3 Expression in HEK-293T Cell Line

The age-related decline in heat-shock proteins--notably heat-shock protein 70 (HSP70)--diminishes the skin's natural stress response and accelerates aging.

Topical Melatonin Promotes Youthful Skin

Molecular cloning and characterization of cDNA encoding a putative stress-induced heat-shock protein from Camelus dromedarius.

ISOLATION, SEQUENCING AND IN SILICO CHARACTERIZATION OF PROMOTER REGION OF HSPA6 GENE FROM ARABIAN CAMEL (CAMELUS DROMEDARIES)

Autologous tumor-derived heat-shock protein peptide complex-96 (HSPPC-96) in patients with metastatic melanoma.

Prophylactic Antitumor Effect of Mixed Heat Shock Proteins/Peptides in Mouse Sarcoma

Variation in the expression of Hsp70, the major heat-shock protein, and thermotolerance in larval and adult selection lines of Drosophila melanogaster.

Expression profile of two HSP70 chaperone proteins in response to extreme thermal acclimation in Xestia c-nigrum (Lepidoptera: Noctuidae)

Engman, "Human antibody responses to Trypanosoma cruzi 70-kD heat-shock proteins," American Journal of Tropical Medicine and Hygiene, vol.

Investigating the chaperone properties of a novel heat shock protein, Hsp70.c, from Trypanosoma brucei

Some like it hot: the structure and function of small heat-shock proteins. Nat Struct Mol Biol.

Heat shock and the heat shock proteins: an overview

"Although heat-shock proteins act as protective chaperones," Dr.

Novel melanoma vaccine to be clinically tested

The heatshock response: regulation and function of heat-shock proteins and molecular chaperones.

Preliminary studies on differential expression of auditory functional genes in the brain after repeated blast exposures

Genomewide transcript analyses of lungs from air- and [O.sub.3] -exposed HeJ and OuJ mice identified a cluster of genes that were significantly up-regulated in Oj-exposed OuJ mice compared with [O.sub.3] -exposed HeJ mice or air-exposed controls of both strains; this cluster included genes for heat-shock proteins (e.g., Hspalb, Hsp70).

Identification of candidate genes downstream of TLR4 signaling after ozone exposure in mice: a role for heat-shock protein 70