Among the GnRH analogue class of medications, elagolix and
goserelin are the least expensive.
European randomized multicenter study of
goserelin (Zoladex) in the management of mastalgia.
Multicenter randomized clinical trial of
goserelin versus surgical ovariectomy in premenopausal patients with receptor-positive metastatic breast cancer: an Intergroup Study.
Combined androgen blockade with
goserelin and bicalutamide was started three years ago.
She was progressing on
goserelin and capecitabine at the time of first blood sample in May 2013, which had amplified ERBB2, TP53 mutation (VAF = 6.5%), and a subclonal PIK3CA mutation (VAF = 2.5%) in cfDNA, suggesting resistant disease.
No metastases were detected, and treatment with both the nonsteroidal antiandrogen bicalutamide (Casodex) and
goserelin (Zoladex) reduced his PSA level to 0.2 ng/mL within three months.
Catamenial epilepsy and
goserelin. Lancet 1991; 338: 1530-0.
The main exclusion criteria were as follows: (1) Pregnancy, (2) current or past history of malignancy, or current contraindication to either
goserelin, Kuntai or Tibolone as documented in the summary of product characteristics for each product, (3) hormone therapy in the last 4 weeks before study entry, or usage of any drug, nutritional supplement, food or Traditional Chinese Medicine against climacteric complaints, (4) psychoactive drugs, (5) body mass index > 28 kg/m [sup]2 , (6) irregular gynecological bleeding in the last 4 weeks before medication start, cervical smear examination with any intraepithelial pathologic change (i.e.
They all had standard chemo, and half also had monthly shots of
goserelin, a drug to lower estrogen and temporarily put the ovaries at rest.
They examined a wide spectrum of testosterone levels, and the adverse effects of different levels, by temporarily suppressing the normal endogenous gonadal steroids of healthy men aged 20-50 years using subcutaneous
goserelin. In one cohort, 198 men then were randomly assigned to receive placebo or 1.25 g, 2.5 g, 5 g, or 10 g of a topical testosterone gel daily for 16 weeks.