Gliosarcoma is a rare primary brain tumour with prevalence varying from 1.5-8% in different studies, and accounts for 0.48% of all intra-cranial tumours.1 It can be further sub-classified into primary
gliosarcoma (PGS) and secondary
gliosarcoma (SGS), and whereas PGS occurs de novo, SGS is believed to occur as a recurrence or progression of Glioblastoma Multiforme (GBM), or as a consequence of radiation therapy.2 The current accepted definition of
gliosarcoma is 'a well-circumscribed lesion with clearly identifiable biphasic glial and metaplastic mesenchymal components'.3,4
Jenkins, "Epithelial and pseudoepithelial differentiation in glioblastoma and
gliosarcoma: a comparative morphologic and molecular genetic study," Cancer, vol.
The report provides comprehensive information on the therapeutics under development for
Gliosarcoma, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type.
Literature review for case reports was completed by searching PubMed using keywords "
gliosarcoma" together with "extracranial" or "skull base." Initial search, primary review, and secondary bibliographic review identified 29 publications from 1985 to 2013.
[USPRwire, Sun Aug 09 2015] Global Markets Direct's, '
Gliosarcoma - Pipeline Review, H1 2015', provides an overview of the
Gliosarcoma's therapeutic pipeline.
Some other congenital tumors like glioblastoma multiforme, congenital neuro-epithelial tumor,
gliosarcoma and medulloblastoma have been reported to be in association with IVF pregnancies (13-15).
Brissette-Storkus et al., "Cytokine gene therapy of gliomas: induction of reactive [CD4.sup.+] T cells by interleukin-4-transfected 9L
gliosarcoma is essential for protective immunity," Cancer Research, vol.
Gliosarcoma is known for its rarity occurrence in older individuals and poor survival.
The authors further investigated the more stable traditional temperature sensitive liposomes carrying doxorubicin and ProHance[R] in vivo in rats bearing 9L
gliosarcoma tumours.
Kruse, "Microglia phagocytose alloreactive CTL-damaged 9L
gliosarcoma cells," Journal of Neuroimmunology, vol.
Spheres isolated from 9L
gliosarcoma rat cell line possess chemoresistant and aggressive cancer stem-like cells.