Medical

gamma-glutamyl transferase

gamma-glutamyl transferase

Gamma-glutamyl transpeptidase Lab medicine An enzyme that catalyzes the transfer of a γ-glutamyl group from glutathione or γ-glutamyl peptide to another peptide or amino acid; GGT is located on the cell membrane and microsomal fractions and is involved in amino acid transport across cell membranes; GGT is highest in the liver–GGT is the best single screening assay for detecting latent or chronic liver disease–eg, CA; in hepatobiliary diseases, a 10-fold + ↑ in GGT is seen in liver cancer, hepatic metastases, and PBC; a 4-fold + ↑ in GGT is seen in chronic active hepatitis, intrahepatic cholestasis, alcoholic hepatitis, extrahepatic biliary obstruction, and inactive cirrhosis.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

gamma-glutamyl transferase

An enzyme widely distributed in body tissues and released into the blood when tissue, especially liver tissue, is damaged. Increased levels occur in liver damage from any cause. Measurements can be used as an index of alcohol abuse. Increased blood levels may sometimes occur without liver cell damage.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
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References in periodicals archive
Reliable markers for HCC diagnosis are aspartate transaminases (AST) and alanine transaminases (ALT) (Whittby et al., 1984), lactate dehydrogenase (LDH) (King, 1965), bilirubin (Harper, 1961), Gamma-glutamyl transferase (GGT) (Yao et al., 2004), alpha feto protein (Sell and Becker, 1978), 5-nucleotidase (5NT) (Sadej et al., 2006), Glucose-6-phosphate dehydrogenase (G6PDH) (Molero et al., 1994) and albumin (Vandenberghe, 1996).
In the RADIANCE Part B trial, the most common adverse reactions that were higher with ozanimod than with interferon beta-1a were upper respiratory tract infections, urinary tract infections, increases of alanine aminotransferase and increases of gamma-glutamyl transferase.
Total bilirubin (0.8 mg/dL), aspartate aminotransferase (13 U/L), alanine aminotransferase (10 U/L), alkaline phosphatase (264 U/L), and gamma-glutamyl transferase (21 U/L) levels were within reference ranges.
Elevated liver enzymes were observed as follows: gamma-glutamyl transferase (GGT; 156 U/L; normal range, 10-71 U/L), alanine transaminase (55 IU/L; normal range, 4-40 IU/L), and aspartate transaminase (90 IU/L; normal range, 4-35 IU/L).
To establish reference intervals for the lipoprotein panel and plasma activity of liver enzymes in common mynahs (Acridotberes tristis), glucose, cholesterol, triglycerides, high and low density lipoprotein concentrations, and activities of aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, and lactate dehydrogenase were measured in 56 adult healthy individuals.
We observed normalization of alkaline phosphatase, AST and ALT, and a significant decrease in gamma-glutamyl transferase, which were attributable to the successful GvHD treatment and immunosuppressive treatment cessation.
an increase of 3.4% with placebo (p=0.029), median reduction in gamma-glutamyl transferase of 30.3% vs.
In the patient, leucocyte was 6.52 x [10.sup.9]/L, hemoglobin was 147 g/L, hematocrit was 46.6%, thrombocyte was 58 x [10.sup.9]/L, aspartate transaminase was 79.8 U/L, alanine transaminase was 116.9 U/L, gamma-glutamyl transferase was 156 U/L, alkaline phosphatase was 1114 U/L, total bilirubin was 0.98 mg/dL, direct bilirubin was 0.6 mg/dL and other biochemistry values were all normal.
The latest research indicates that ongoing CBCs really aren't necessary, and that, GGT (gamma-glutamyl transferase), which is liver specific, is a far better option than ALT/ AST to keep tabs on the liver.
Consistent with normal plasma gamma-glutamyl transferase (GGT) and procollagen type 1 N- terminal propeptide (P1NP), isoenzyme electrophoreses did not demonstrate a predominant liver or bone fraction (Fig.
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