For the 12 months ending 31 October 2016, the
Fosphenytoin Sodium Injection USP, 75 mg/ml, (50 mg PE/ml), packaged in 100 mg PE/2 ml, and 500 mg PE/10 ml single-use vials had US sales of approximately USD36.3m, according to IMS Health.
Until the FDA completes the evaluation, "health care providers should consider avoiding phenytoin and
fosphenytoin as alternatives for carbamazepine in patients who test positive for HLA-B*1502."
However, because the potential risks associated with phenytoin and
fosphenytoin still are being investigated, "there is not yet enough information to recommend testing" for the allele in patients of Asian ancestry being considered for treatment with one of these two antiepileptic drugs.
Fosphenytoin was created to overcome some of the limitations of phenytoin.
Newer antiepileptic drugs: gabapentin, lamotrigine, felbamate, topiramate and
fosphenytoin. American Family Physician.
These medications include phenobarbital, primidone (Mysoline), phenytoin (Dilantin), carbamazepine (Tegretol),
fosphenytoin (Cerebyx), and valproic acid (Depakote).
ampicillin (Polycillin) ciprofloxacin (Cipro) Anticonvulsants: Act on the central nervous ethosuximide (Zarontin) system to reduce number
fosphenytoin (Cerebyx) and severity of seizures.
Fosphenytoin (1) and mycophenolate mofetil (MMF) (2) are two examples of prodrugs where monitoring of the active drug, the anticonvulsant phenytoin and the immunosuppressant mycophenolic acid (MPA), respectively, is used to guide therapy.
New antiepileptics approved in the 1990s include felbamate, gabapentin, lamotrigine, topiramate, tiagabine, and
fosphenytoin (Pellock, 1996).
She was treated acutely with lorazepam and loaded on both Keppra and
fosphenytoin, and her seizures stopped.
NEW YORK -- Amneal Biosciences, a unit of Amneal Pharmaceuticals LLC, has launched its first product: generic
fosphenytoin sodium injection.