Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty: a prospective, randomised, double-blind study of 86 patients.
White blood cell (WBC) count, CRP, hs-CRP, procalcitonin,
fibrinolytic system markers including DD, FDPs, fibrin monomers, and natural anticoagulant proteins such as protein C, protein S, and antithrombin III were investigated by means of the blood samples.
Nattokinase, one of the most studied microbial proteases, is a
fibrinolytic enzyme produced by Bacillus subtilis.
If primary PCI cannot be performed timely after STEMI diagnosis,
fibrinolytic therapy is recommended within 12 hours of symptoms in patients without contra-indications.
SSc patients are characterized by increased plasma D-dimer values reflecting a potential activation of both the coagulation and
fibrinolytic pathways, which might finally predispose these patients to thrombotic complications.
Most research indicated that lumbrokinase is primarily a
fibrinolytic enzyme and it possesses both direct and indirect
fibrinolytic effects.
The success rate with
fibrinolytic therapy was low overall (59%) and very low in patients in New York Heart Association functional class III/IV (24%)9.
Global
fibrinolytic activity in plasma was determined by a fibrin plate assay [32].
Although not statistically significant, survival to hospital discharge was also higher in the
fibrinolytic therapy group (19% versus 7%) [33].
[Table 2] presents proteolytic (ml/h) and
fibrinolytic ([micro]g azofibrin/ml per 1 h) EBC activity in children from the groups of observation.{Table 2}