We also previously showed [8] that extradural anesthesia added to general anesthesia resulted in lower concentrations of cortisol and growth hormone than did general anesthesia alone, but IL-6, CRP, and Zn concentrations did not change significantly.
Because MT is induced by glucocorticoids [9][10] and IL-6 [11], we examined the effects of the decreased pituitary adrenal response in extradural anesthesia on MT production.