Epidemiology and distribution of human herpesvirus (HHV-6) variants Variant A Variant B Associated pathologic conditions Exanthem subitum -(a) ++++ febrile syndromes(b) Multiple sclerosis ++ ++ Lymphomas and neoplasies ++ ++ Reactivation in transplants ++ ++ Reactivation in AIDS ++ ++ Tissue distribution Peripheral blood + +++ mononuclear cells Salivary glands - ++++ Skin ++ ++ Brain ++ ++ Lymph nodes - ++++ Other tissues - ++++ Serum from healthy persons - - Serum from exanthem - ++++ subitum patients Serum from other patients(c) +++ + Saliva - ++++ Cerebrospinal fluid +++ +
(8), who investigated the correlation between seroconversion to HHV-6B and childhood infectious diseases and found that seroconversion occurs concomitantly with roseola infantum, also designated exanthem subitum or sixth disease, a common, mild, acute febrile disease of infants.
HHV-6B is not the only causative agent of exanthem subitum. Occasionally, HHV-7 may also cause fever with or without rash.
In addition to the salivary glands, HHV-6 has been frequently isolated from cultured PBMCs from AIDS patients or children with exanthem subitum or febrile illnesses.