A total of 117 patients diagnosed with depression were randomly divided in two groups: Group I (58 patients) received Tablet amisulpride 50 mg/day orally and Group II (59 patients) were given Tablet
escitalopram 10 mg/day orally.
The subjects were divided into three groups, two were double blinded and received
Escitalopram or placebo and one was non-blinded and underwent therapy with problem solving techniques.
Lenze and his colleagues showed that during a lead-in phase with 12 weeks of open-label
escitalopram, patients showed a modest reduction in worry symptoms on the Penn State Worry Questionnaire, but if they then had CBT added, they showed a substantial further reduction in worry, compared with those who did not receive CBT.
Pharmacologic options beyond the three SSRIs backed by placebo-controlled, randomized trial evidence sertraline, citalopram, and
escitalopram --include the various other SSRIs.
A 15-year-old Caucasian female with a past medical history significant for depression presented to the emergency department following a suicide attempt after ingesting approximately 500 milligrams of
escitalopram. She presented with lethargy and dizziness.
Individuals with any of the following conditions were excluded: (a) serious suicidal ideation based on the clinician's evaluation; (b) any serious physical illness; (c) any history of epilepsy; (d) history of closed-angle glaucoma; (e) abuse of or dependence on alcohol or any psychoactive drug during the past year; (f) depressive episode induced by other mental or physical illnesses; (g) lactation, current pregnancy, or any possible pregnancy during the trial; (h) history of severe drug allergy; or (i) a history of poor response to
escitalopram.
Perlis cautions that the results of this study should not cause patients taking citalopram or
escitalopram to stop taking their medication.
Separately, the FDA has approved the first genetic Lexapro (
escitalopram tablets) to treat depression and generalized anxiety disorder in adults.
In May 2002, Lundbeck granted a licence for
escitalopram -- the active ingredient in Lexapro -- in Japan to Mochida, which in January 2010 signed an agreement to co-market the drug with Mitsubishi Tanabe Pharma.
The selective serotonin reuptake inhibitor
escitalopram rapidly reduces the frequency and severity of hot flashes in menopausal women, according to a report.
Rhabdomyolysis and Acute Renal Failure in a Recurrent Depressive Patient Treated with
Escitalopram and Quetiapine: Case Report