dose

[dōs]

the quantity to be administered at one time, as a specified amount of medication or a given quantity of radiation.

absorbed dose that amount of energy from ionizing radiations absorbed per unit mass of matter, expressed in rads.

air dose the intensity of an x-ray or gamma-ray beam in air, expressed in roentgens.

booster dose an amount of immunogen (vaccine, toxoid, or other antigen preparation), usually smaller than the original amount, injected at an appropriate interval after primary immunization to sustain the immune response to that immunogen.

curative dose (CD) a dose that is sufficient to restore normal health. See also median curative dose.

divided dose fractionated dose.

effective dose (ED) that quantity of a drug that will produce the effects for which it is administered. See also median effective dose.

erythema dose that amount of radiation that, when applied to the skin, causes erythema (temporary reddening).

fatal dose lethal dose.

fractionated dose a fraction of the total dose prescribed, as of chemotherapy or radiation therapy, to be given at intervals, usually during a 24-hour period.

infective dose (ID) that amount of a pathogenic agent that will cause infection in susceptible subjects. See also median infective dose and tissue culture infective dose.

lethal dose (LD) that quantity of an agent that will or may be sufficient to cause death. See also median lethal dose and minimum lethal dose.

loading dose a dose of medication, often larger than subsequent doses, administered for the purpose of establishing a therapeutic level of the medication.

maintenance dose the amount of a medication administered to maintain a desired level of the medication in the blood.

maximum tolerated dose tolerance dose.

maximum permissible dose the largest amount of ionizing radiation that one may safely receive within a specified period according to recommended limits in current radiation protection guides. The specific amounts vary with age and circumstance.

median curative dose (CD₅₀) a dose that abolishes symptoms in 50 per cent of test subjects.

median effective dose (ED₅₀) a dose that produces the desired effect in 50 per cent of a population.

median infective dose (ID₅₀) that amount of pathogenic microorganisms that will produce demonstrable infection in 50 per cent of the test subjects.

median lethal dose (LD₅₀) the quantity of an agent that will kill 50 per cent of the test subjects; in radiology, the amount of radiation that will kill, within a specified period, 50 per cent of individuals in a large group or population.

median tissue culture infective dose (TCID₅₀) that amount of a pathogenic agent that will produce infection in 50 per cent of cell cultures inoculated.

minimum lethal dose

1. the amount of toxin that will just kill an experimental animal.

2. the smallest quantity of diphtheria toxin that will kill a guinea pig of 250-gm weight in 4 to 5 days when injected subcutaneously.

reference dose an estimate of the daily exposure to a substance for humans that is assumed to be without appreciable risk; it is calculated using the no observed adverse effect level and is more conservative than the older margin of safety.

skin dose (SD)

1. the air dose of radiation at the skin surface, comprising the primary radiation plus backscatter.

2. the absorbed dose in the skin.

threshold dose the minimum dose of ionizing radiation, a chemical, or a drug that will produce a detectable degree of any given effect.

threshold erythema dose (TED) the single skin dose that will produce, in 80 per cent of those tested, a faint but definite erythema within 30 days, and in the other 20 per cent, no visible reaction.

tissue culture infective dose (TCID) that amount of a pathogenic agent that will produce infection when inoculated on tissue cultures; used with a numeric qualifier.

tolerance dose the largest quantity of an agent that may be administered without harm. Called also maximum tolerated dose.

er·y·the·ma dose

the minimum amount of x-rays or other form of radiation sufficient to produce erythema; historically, this dose was indicated by the Sabouraud meter as the B tint, the Holzknecht as 5(5H), the Hampson as 4, and the Kienbock as 10.

Farlex Partner Medical Dictionary © Farlex 2012

er·y·the·ma dose

(er'i-thē'mă dōs)

The minimum dose of x-rays or other forms of radiation sufficient to produce erythema.

Medical Dictionary for the Health Professions and Nursing © Farlex 2012

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References in periodicals archive

Minimal erythema dose (Med) to narrow band ultraviolet--B (NB-UVB) and broad band ultraviolet-B (BB-UVB): A pilot study.

Evaluation of narrow-band UVB phototherapy for vitiligo

Table 1 presents the doses of intensity of UVA and UVB radiation, the doses emitted due to the radiation and minimum erythema doses, disseminated by the welding process, using different materials at the welding process and under different intensity of the source.

Assessment of ultraviolet (UV) radiation from technical sources/Dirbtiniu saltiniu skleidziamos UVA ir UVB spinduliuotes ivertinimas

It has been suggested that receiving the equivalent of one minimal erythema dose to the hands and face per week is sufficient for vitamin D synthesis, Dr.

Melanoma experts grapple with the sun question: one hypothesis is that vitamin D may help protect against cancer, but epidemiologic evidence is scant

Recently however due to the increasing evidence of vitamin D deficiency in the South-Asian population living in the UK a group of researchers based in Manchester (UK) have conducted a study in the South-Asian population with exposure of UVB doses ranging from 0.65 to 3.9 standard erythema dose (SED) thrice weekly to 35% body surface area i.e.

Defeat the D' deficiency be sun smart

However, a recent trial of both vitamins together reported that the combination provided significant UV protection, increasing the minimal erythema dose by an average of about 50% in just a single week, Dr.

Chemoprevention of skin cancer making strides: in this highly active field, promising agents include retinoids, statins, NSAIDs, and vitamins C, D, and E

Depending on the minimal erythema dose (MED) of skin type the patients were irradiated using all the protective measures.

Efficacy and safety of narrowband ultraviolet B therapy in moderate to severe atopic dermatitis

It's essential to determine each individual's minimum erythema dose before starting the annual course of treatment, as photosensitivity in these patients varies considerably from year to year.

Photochemotherapy is workhorse for chronic actinic dermatitis: sunscreen of little value

Relative protection was measured on the basis of the minimal erythema dose with each application of sunscreen, they said.

Reapply That Sunscreen

The doses ranged from 0.65-3.9 standard erythema doses (SED), which were equivalent to 15-90min of unshaded noontime summer sunlight exposure under a clear sky in Manchester, 53.5 degrees north.

Simulated sunshine and vitamin D status

The cumulative solar UVB exposure was calculated in Minimal Erythema Doses (38.3 [+ or -]12.8 MEDs).

Changes in serum vitamin D levels following Dead Sea climatotherapy