Komossa et al (25) found that risperidone is less
epileptogenic than clozapine, with a relative risk of .(22).
But interestingly, three cases in the ADHD group showed abnormal focal
epileptogenic activity in the frontal lobe in their EEGs despite negative previous history of seizures.
The patient was monitored closely for convulsive and/or nonconvulsive seizures during the time of her admission by three-day video EEG monitoring, and three spot EEGs, all within 10 days of the CT perfusion, and none of them demonstrated the transformation of the
epileptogenic discharges into seizures.
Moreover, in TLE, hyper-excitability in the hippocampus is also seen during the process of epilepsy development and can contribute to an
epileptogenic focus by inducing atrophy of the hippocampus (see review [45-49]).
During the UHW operation, Professor William Gray used the neuromate's robotic arm and spent 55 minutes identifying and operating on the "
epileptogenic zone" in a procedure that would normally take four hours.
No correlation was found between the laterality of the
epileptogenic focus in the epilepsy group and existence of IHI, nor between age and HIA values among the groups.
The
epileptogenic network in MTLE also varies between individuals.
It is therefore possible that some developmental or childhood brain injury has occurred in a person with ApoE [epsilon]4, and there may be a failure to repair the damage, resulting in an
epileptogenic lesion.