electrospray ionisation
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electrospray ionisation
A process in mass spectrometry in which a solution containing the molecules of interest is pumped through a metal capillary tube maintained at a high potential. The solution is sprayed from the tube into a chamber held at ground potential and open to atmospheric pressure.
The sample solution spray’s droplets carry a charge induced by the needle potential; the droplets in the mist become progressively smaller as neutral solvent molecules evaporate. The charge is maintained on the droplets’ surfaces, eventually causing an instability that results in the expulsion of solvent-less, highly charged ions of the dissolved sample molecules. Multiple protonation forms highly charged sample molecules of the form (M nH)n.Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive
Screening for medium chain acyl-CoA dehydrogenase deficiency using
electrospray ionisation tandem mass spectrometry.
Determination of glutathionyl hemoglobin in hemodialysis patients using
electrospray ionisation liquid chromatographymass spectrometry.
Electrospray ionisation mass spectrometry identification of fibrinogen Banks peninsula (y280Tyr [right arrow] Cys): a new variant with defective polymerisation.
Albumin Church Bay: 560Lys [right arrow] Glu: a new mutation detected by electrospray ionisation mass spectrometry.
A reactive, surface cysteine residue of the class-II fructose-1,6-bisphosphate aldolase of Escherichia coli revealed by
electrospray ionisation mass spectrometry.
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