Diffuse pulmonary lymphoreticular infiltrations associated with
dysproteinemia. Med Clin North Am.
The six reported cases and our case occurred with or without clinically apparent myeloproliferative disorders, such as multiple myeloma, monoclonal gammopathy of undetermined significance, or
dysproteinemia. Although bone marrow puncture was not performed in our case, no abnormalities in protein electrophoresis of serum and urine or the serum free light chain ratio were observed; therefore, the involvement of myeloproliferative diseases was excluded.
175 patient serum samples with previously quantified M-proteins (range 0.2-6.2 g/dL) of known isotype (62 IgG, 36 IgA, and 77 IgM) were pulled from the Mayo Clinic
Dysproteinemia Biobank (Cohort 2d).
California-based anatomic and clinical pathologist Gamble has produced a detailed guide based on 147 cases of renal involvement associated with
dysproteinemia in university and community hospital settings over some 25 years.
*
Dysproteinemia can cause crops of petechiae and occasionally ecchymoses.
* Patients with
dysproteinemia (e.g., hemoglobinopathy, gout, Waldenstrom's Macroglobulinemia).
All queries to the Laboratory Information System or
Dysproteinemia database followed a protocol on the "Natural History of Monoclonal Gammopathies," approved by the Mayo Clinic Institutional Review Board.
Cutaneous involvement in patients with angioimmunoblastic lymphadenopathy with
dysproteinemia: a clinical, immunohistological, and molecular analysis.
Malignant lymphoma, plasmacytosis,
dysproteinemia. Arch Intern Med.
Spurious hyperphosphatemia in patients with
dysproteinemia is well documented (6, 7).
The 4 categories include (1) crystalline nephropathies seen in the setting of
dysproteinemia, (2) drug-induced crystalline nephropathies, (3) crystalline nephropathies related to calcium deposition, and (4) metabolic and genetic forms of crystalline nephropathy.
(9) contains several important lessons that resonate with our own clinical laboratory experience, which involved a large
dysproteinemia clinical practice, and our publications on diagnostic detection limit, which were from clinical trials and/or studies with well-defined patient groups.