Involutional, age 50-80% Treatment Clomiphene, tamoxifen, testolactone, surgery. See
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Gynecomastia Etiology
Endocrinopathy Orchitis, hypogonadism–androgen deficiency, androgen resistance, tumors/hyperplasia of adrenal gland, testes, eg Leydig cell tumor–↑ hCG, lung CA, Klinefelter syndrome–↑ risk of breast CA and thyroid hyperplasia
Drugs α-methyldopa, amphetamine, androgens, benzodiazepines, cimetidine, chemotherapeutics, digitalis, INH, marijuana, penicillamine, phenothiazine, reserpine, spironolactone, tricyclic antidepressants
Other conditions Starvation diet–mechanism: testicular, hepatic hypofunction or on resuming feeding, hemodialysis, liver disease–cirrhosis, hepatomas, hemochromatosis, due to ↓ hepatic metabolism of estrogens, mycosis fungoides, myotonic dystrophy with spastic paraplegia, leprosy
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