Medical

drug-transporter gene

drug-transporter gene

One of a range of genes that code for transport proteins to which various drug molecules can attach. An example of the product of such a gene is the ABCB1 transporter (also known as MDR1) which is known to transport at least four anti-epileptic drugs. Mutations in this gene can cause multi-drug-resistant epilepsy. ABCB1 (MDR1) contributes to drug resistance in a number of diseases including several cancers, RHEUMATOID ARTHRITIS and inflammatory bowel disease.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
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References in periodicals archive
Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1.
THE IMPACT OF ABCB1 (C3435T) POLYMORPHISM ON THE EFFICACY OF ONDANSETRON FOR POST-OPERATIVE NAUSEA AND VOMITING IN PAKISTANI POPULATION
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