Dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of TP53, BAX, BCL2 and cleaved CASP3.
Summary: Two new alkaloidal steroid glycosides; solanoid A and B (1 and 2), along with two known alkaloidal steroid glycosides; solamargine (3) and khasianine (4) a known steroidal saponin;
dioscin (5), a benzoylated steroid, carpesterol (6) methyl caffeate (7), ferulic acid (8) and oleic acid (9) were isolated from the methanolic extract of Solanum surattense.
The fresh rhizome contains various saponins such as Huangjiangsu A, zingiberensis new saponin, deltonin,
dioscin, and gracillin (Table 1) [11].
The plant contains saponins; these are glycosides, such as diosgenin,
dioscin and dioscorin, and are used in the manufacture of steroids.
Amongst these compounds, diosgenin, a well-known steroidal sapogenin which originated by the hydrolysis of the saponin
dioscin (Figure 1), which can be obtained from several plants, namely, from Dioscorea, Trigonella, Costus [5-7], and Smilax species [8], is classically used in traditional medicine against a variety of medical conditions.
Dioscin is a natural steroid saponin that presents in various plants.
It is synthesized through UV irradiation of
dioscin, which is extracted from Chinese yams or soybeans.
Diosgenin, a steroid sapogenin of the saponin
dioscin, can undergo oxidation to produce a progesterone-like structure that has been used to synthesize human sex hormones and to treat conditions that are regulated by these hormones.
Yin et al., "
Dioscin reduces lipopolysaccharide-induced inflammatory liver injury via regulating TLR4/MyD88 signal pathway," International Immunopharmacology, vol.