dimethylsulfoxide

(dī-mĕth′əl-sŭl-fŏk′sīd′)

DMSO.

DMSO

Alternative medicine
A substance that occurs naturally in minute amounts in certain foods, which has industrial and health-related applications. Animal studies have shown it to have analgesic, anti-inflammatory, antimicrobial, vasodilatory and other properties; up to the 1960s, DMSO had been administered orally, topically or parenterally by mainstream physicians for various conditions, including arthritis, bursitis, cancer, emphysema, mental illness and pain. In the face of its association with lenticular degeneration, DMSO was removed from general use; some practitioners of alternative healthcare continue to recommend DMSO for these and other uses.

Toxicity
Topical DMSO is associated burning, itching and an unpleasant odour.

Mainstream medicine
DMSO is FDA-approved for treating interstitial cystitis, and may be of use in treating scleroderma, sprains, arthritis, cerebrovascular accidents, familial amyloidotic polyneuropathy and acetaminophen hepatotoxicity. DMSO reduces the ice crystals formed in frozen section tissues from the operating suite, and may be an effective cryopreservative.

Mentioned in

References in periodicals archive

Note: DBT, dibutyltin; DMSO, dimethylsulfoxide; SEM, standard error of the mean; TBT, tributyltin.

Effects of Perinatal Exposure to Dibutyltin Chloride on Fat and Glucose Metabolism in Mice, and Molecular Mechanisms, in Vitro

In the present study, data on density, viscosity, refractive index, and speed of sound of binary mixtures of dimethylsulfoxide (DMSO) + 1-phenylethanone (acetophenone) and 1,4-Dimethylbenzene (para-xylene) at 313.15, 318.15, 323.15, and 328.15 K has been measured experimentally.

Thermophysical properties of binary mixtures of dimethylsulfoxide with 1-phenylethanone and 1,4-dimethylbenzene at various temperatures

Graham, "Dimethylsulfoxide (DMSO) treatment reduces infarction volume after permanent focal cerebral ischemia in rats," Neuroscience Letters, vol.

Role of matrix metalloproteinase activity in the neurovascular protective effects of angiotensin antagonism

(2,5,7-10,13-15) Antimicrobial and anti-inflammatory products (eg, dimethylsulfoxide, hemorrhoid cream, triple antibiotic ointment, silver sulfadiazine cream) as well as hypertonic footbaths (eg, hypertonic saline solution, magnesium sulfate) provide local control of infection and inflammation.

Advancement flap as a novel treatment for a pododermatitis lesion in a red-tailed hawk (Buteo jamaicensis)

RPMI-1640 medium, fetal bovine serum (FBS), penicillin, and streptomycin were purchased from Sigma (Germany), dimethylsulfoxide (DMSO) and trypan blue from Merck (Germany), trypsin/EDTA solution from Gibco (U.K), and 3-(4,5-dimetylthiazol-2-YL)-2,5-diphenyltetrazolium bromide (MTT reagent), Cell Death Detection ELISA plus kit, and In Situ Cell Death Detection Kit, POD from Roche Diagnostics GmbH (Germany) and DAB (3, 3'-diaminobenzidine).

Induction of apoptosis by grape seed extract (Vitis vinifera) in oral squamous cell carcinoma

(a) XPNPEP2 Clinical Genotype (c) Setting 1 C/ Allergic reaction; vascular surgery 2 C/C TACO; anemia and CHF 3 C/ DMSO toxicity; AML 4 C/C(C/) Nonhypotensive reaction Abbreviations: AML, acute myelogenous leukemia; CHF, congestive heart failure; DMSO, dimethylsulfoxide; FFP, fresh-frozen plasma; NK, not known (because of deidentification of data prior to analysis); PBSC, peripheral blood stem cells; RBC, red blood cells; TACO, transfusion-associated circulatory overload.

The development of a novel molecular assay examining the role of aminopeptidase P polymorphisms in acute hypotensive transfusion reactions

The solvent dimethylsulfoxide (0.1%) was used as a vehicle and control.

Palmitic acid induces production of proinflammatory cytokines interleukin-6, interleukin-1[beta], and tumor necrosis factor-[alpha] via a NF-[kappa]B-dependent mechanism in HaCaT keratinocytes

The plates were destained for approximately 10 min with an aqueous solution of 10% acetic acid and 2% dimethylsulfoxide.21

Analysis of antibacterial and antifungal activity of crude extracts from seeds of coriandrum sativum

1) like CH3CN (MeCN), CHCl3 (CF), CH2Cl2 (DCM), CH3OH (MeOH), dimethylformamide (DMF) and dimethylsulfoxide (DMSO) at 2.8x10-5 M.

Selective Cation Recognition by p-Tetranitrocalix[4]arene

Samples were dissolved in dimethylsulfoxide (DMSO) and diluted with artificial sea salt water so that final DMSO concentration did not exceed 0.05%.

Assessment of bioactivity of Bangladeshi medicinal plants using brine shrimp lethality assay