Less attention has been paid to the role of other cell types, namely, delta cells. Previously, besides insulin secretion also the SST secretion as a response to glucose was found impaired in the perfused pancreas of GK rats [23]; hence we specifically focused on delta cells and SST PI content in fully developed diabetes.
Investigating young 6-week-old rats, we found that the number of SST-positive delta cells was not higher in GK rats versus Wistar controls (15% [+ or -] 3% of summary cell counts in GK rats versus 18% [+ or -] 5% in Wistar rats).
This protein has also been found to bind antigens that are produced in large amounts in tumour cells, which then activates gamma delta cells against these tumour cells.
Prof De Libero said, "The identification of the molecular mechanisms of how human gamma delta cells get activated opens doors to novel opportunities for immunotherapy of infections and tumours."