Budesonide is a locally acting corticosteroid that Puma believes targets the inflammation identified in a preclinical model of neratinib-induced diarrhea and
colestipol is a bile acid sequestrant that Puma believes targets potential bile acid malabsorption that could result from such inflammation.
More recently, rounded structures have been occasionally described with BAS, specifically
colestipol (26) (Figure 6).
Reports of fetal harm have not been located for the other two agents in this class, but there is only one case report involving five women for colesevelam and no reports for
colestipol. Nevertheless, both of these drugs have the potential to cause fetal hemorrhage if they are taken for prolonged periods in pregnancy.
There are four classes of lipid-lowering drugs in the market: the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (the "statins"), the fibrates (gemfibrozil, clofibrate, and fenofibrate), niacin/nicotinic acid, and the bile acid binding resins (
colestipol and cholestyramine).
* Cholesterol-lowering drugs:
Colestipol (Colestid), cholestyramine (Questran), and colsevelam (Welchol)
Diclofenac bioavailability can be reduced by a variety of agents including
colestipol, cholestyramine (Al-Balla et al., 1994) and aspirin (Todd and Sorkin, 1988), but can be increased by other drugs such as diosmin, likely by inhibition of CYP2C9 (Rajnarayana et al., 2007).
Based on the differential diagnosis, he was initially managed with soluble fiber,
colestipol, and loperamide, which achieved constipation.
Bile acid sequestrants (cholestyramine,
colestipol, colesevelam) may reduce blood glucose and increase triglycerides, and careful monitoring should be done in people with diabetes.
The three main bile acid sequestrants currently prescribed in the United States are cholestyramine resin (Questran),
colestipol (Colestid) and colesevalam (WelChol).