cold au·to·ag·glu·ti·nin

an antibody that agglutinates particulate antigens (that is, bacteria) at temperatures below 37°C, often most actively at 4°C; most are the IgM class of immunoglobulins with affinity for the Ii system of erythrocyte antigens, but some are anti-Pr cold autoagglutinins; cold autoagglutinins may be associated with infection (for example, primary atypical pneumonia, infectious mononucleosis and other virus infections, certain protozoan infections) and in such instances usually are not active in vivo.

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