The most frequent nucleotides at the first, second and third
codon positions were C (28.9%, 29.7%), T (40.0%, 39.0%), C (40.5%, 39.3%) in P.
Polymorphisms in
codon 194 (allele frequency 13%),
codon 280 (allele frequency 7%), and
codon 399 (allele frequency 27%) are intensively studied due to their high allele frequency and functional significance (16-17).
The G>A polymorphism in
codon 312 of the exon 10 results in Asp>Asn substitution.
Proteins are coded by twenty different types of amino acids with all amino acids having more than two
codons, except Methionine and Tryptophan which have single
codon.
Deletion of one
codon was also observed at position 518 in an isolate associated with RIF resistance (Table-1).
To maintain tissue homeostasis, apoptosis plays a key role by removing dysfunctional cellular debris especially in ectopic endometrial foci.11 A total 14 polymorphisms of TP53 have been reported to date.12 The most important one is rs1042522 which lies in exon 4
codon 72 region.
(4) No false start/stop
codon: false start/stop
codons are prevented via false
codon searching both in an integer value and between consecutive integer values.
Mutation in the katG gene at the
codon S315T1 was found to be the most frequent, with 151 (20.9%) isolates showing this mutation.
Polymerase chain reaction was carried out to obtain the desired DNA sequences (containing
codon 12 and 13 of the K-RAS gene) using the designed primers, and the Big Dye Terminator, Applied Biosystem's buffer and water.
(9) Mutations at
codon 407, 410, 420, 425 (456 now) and insertions between 408 and 409 have been confirmed to be associated with rifampicin resistance and were also supported by MFP studies.
Objective: The polymorphism in
codon 399 of the X-ray repair cross-complementing group 1 (XRCC1) gene may subtly alter structure of DNA repair enzymes and modulate the repair capacity.