clusterin

[klus´ter-in]

a multifunctional glycoprotein with roles in the metabolism and transport of lipids and membrane fragments, secretion of hormones, reproductive biology, inhibition of assembly of the membrane attack complex of complement activation, programmed cell death, and modulation of intercell interactions; its expression is enhanced in tissue injury and remodeling as well as in degenerative diseases such as alzheimer's disease.

clusterin

(klŭs'tĕr-in),

Heterodimeric highly conserved secreted glycoprotein, which is expressed in a wide variety of tissues and found in all human fluids; implicated in physiologic processes such as sperm maturation, lipid transportation, complement inhibition, tissue remodeling, membrane recycling, cell-cell and cell-substratum interactions, stabilization of stressed proteins in a folding-competent state and promotion or inhibition of apoptosis.

Synonym(s): apolipoprotein J

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References in periodicals archive

The role of human kallikrein 6, clusterin and adiponectin as potential blood biomarkers of dementia.

Determination of Adiponectin, Tumor Necrosis Factor-Alpha, and Adhesion Molecules in Alzheimer's Disease

Another AD risk gene is clusterin (CLU) known as apolipoprotein J (APOJ) (14), and it directly binds A[beta] and regulates the A[beta] pathology (15).

Analysis of the BACE1 and Clusterin Genes Expression Levels in Alzheimer's Disease/Alzheimer Hastaliginda BACE1 ve Clusterin Genleri Ekspresyon Seviyelerinin Analizi

The tumor cells consistently express vimentin, with variable positivity for D2-40, CD34, CD68, smooth muscle actin, keratin, and p53, but lack other mesenchymal, epithelial markers, such as S100 protein, desmin, neuron-specific enolase, epithelial membrane antigen, HMB-45, clusterin, and leukocyte markers (CD15, CD30, CD45).

The t(1;10)(p22;q24) TGFBR3/MGEA5 Translocation in Pleomorphic Hyalinizing Angiectatic Tumor, Myxoinflammatory Fibroblastic Sarcoma, and Hemosiderotic Fibrolipomatous Tumor

In AD, amyloid precursor protein (APP) and presenilin (PS) are already the definitive virulence genes.[1] For SAD >90% of AD, major influencing genes include apolipoprotein E (ApoE) gene, clusterin gene, complement receptor 1 gene, and phospholipids bind to clathrin protein (PICALM) gene.[2] Along with the development of genetic research into AD, more new genetic loci for AD have been discovered, including cholesterol metabolism gene (CH25H, ABCAL, and CH24H),[3] Sterol O-acyltransferase (Soat1) and prostaglandin-endoperoxide synthase 2 (Ptgs2)[4] genes, and angiotensin-converting enzyme gene [5] are some of these.

Research Progress in the Pathogenesis of Alzheimer's Disease

Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney.

Ginsenoside Rg1 protects human renal tubular epithelial cells from lipopolysaccharide-induced apoptosis and inflammation damage

Salminen, "Valproic acid stimulates clusterin expression in human astrocytes: implications for Alzheimer's disease," Neuroscience Letters, vol.

Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice

Mattsson et al., "Complement and clusterin in the spinal cord dorsal horn and gracile nucleus following sciatic nerve injury in the adult rat," Neuroscience, vol.

Impaired Autophagy of GABAergic Interneurons in Neuropathic Pain

Clusterin (CLU) is a stress-induced chaperone involved in neuronal protection [38].

Differential Proteomic Analysis Predicts Appropriate Applications for the Secretome of Adipose-Derived Mesenchymal Stem/Stromal Cells and Dermal Fibroblasts

The tumor cells were also negative for HMB-45, CD15, CD20, CD21, CD23, CD43, CD45, desmin, myogenin, calretinin, myeloperoxidase, D2-40, CD68, and clusterin (Figure 1(e)).

Undifferentiated Pleomorphic Sarcoma of Liver: Case Report and Review of the Literature