Apoptosis and necrosis in the
circumventricular organs after experimental subarachnoid hemorrhage as detected with annexin V and caspase 3 immunostaining.
The
circumventricular organs. Histol Histopathol 32(g), 879-892.
Past experiments in which researchers had elecrically stimulated various
circumventricular organs in the brain of mice, including the SFO, had yielded inconsistent results.
The MnPO receives inputs from the circumventricular organs and peripheral osmoreceptors with reciprocal connections with paraventricular nucleus of hypothalamus (PVN), parabrachial nucleus, and ventrolateral medulla that are involved in cardiovascular regulations [14, 27-31].
Ciriello, "Effect of lesions of forebrain circumventricular organs on c-fos expression in the central nervous system to plasma hypernatremia," Brain Research, vol.
The circumventricular organs are chemosensitive cells that are highly innervated with fenestrated capillaries.
In these circumventricular organs (Figure 6-7), blood from the arteries supplying the brain enters capillary networks consisting of fenestrated capillaries and then returns to the venous circulation via the venous sinuses.
Aquaporin-4 is highly expressed in areas which either lack an endothelial blood-brain barrier (circumventricular organs)7 or where blood-brain barrier permeability is higher compared to other regions of the CNS, such as the optic nerve head.
Particular attention should be paid to lesions in circumventricular organs and the optic nerve head, since in both regions the blood-brain barrier is less tight than in other regions of the CNS, and AQP-4 is highly expressed at these sites.