PPAR[alpha] is mainly expressed in the liver and heart, where it is activated by endogenous activators such as fatty acid derivatives (i.e., eicosanoids, palmitic, oleic, and linoleic acids) or exogenous ligands, such as the Wy14,643 compounds or fibrate drugs (i.e., gemfibrozil, clofibrate,
ciprofibrate, and fenofibrate) [18].
leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with
ciprofibrate," Thrombosis Research, vol.
Validation of a spectrophotometric method to determine
ciprofibrate content in tablets.
The compound worked in a similar way to the commercial drug
ciprofibrate, which lowers the 'bad' form of low-density lipoprotein (LDL) cholesterol and tryglicerides, a blood fat linked to heart disease.
injection, to the PPAs, clofibrate (CLO) or the more potent
ciprofibrate (CPR), did not exhibit any changes in hepatic microsomal lauric acid hydroxylase (LA-OHase) activities, although kidney microsomal [omega] and [omega]-6 products were increased significantly.
Effect of
ciprofibrate on fibrinogen synthesis in vitro on hepatoma cells and in vivo in genetically obese Zucker rats.
Rimando and her colleagues found that the triglyceride-lowering ability of pterostilbene rivals that of
ciprofibrate.
Ciprofibrate increases paraoxonase activity in patients with metabolic syndrome.