Documentation by the physician that signals that 631.0 should be reported might include a reference to biochemical pregnancy,
chemical pregnancy, or an inappropriate level of quantitative hCG for gestational age in early pregnancy.
There was no difference between the study and control groups regarding chemical pregnancy (36.4% vs.
Outcome measures of cycles in study and control groups Transdermal Oral Parameter (Unit) patch (n=45) (n=45) P-value Implantation rate 20.45% 11.7% 0.13 Chemical pregnancy 16 (36.4%) 13 (31%) 0.65 rate/cycle Clinical pregnancy 16 (36.4%) 12 (28.6%) 0.29 rate/cycle Clinical 0 (0%) 2 (4.8%) 0.23 abortion rate
Of the 2,350 couples in the main study, 765 women were selected by the outcome of their first IVF cycle (failed implantation, chemical pregnancy, spontaneous abortion, or live birth).
A chemical pregnancy was defined by a post-ET hCG measurement of [greater than or equal to] 5.0 mIU/mL with no further embryonic development (gestational sac or yolk sac).
Chemical pregnancy was detected by serum hCG determination 14 days after embryo transfer (ET) and was confirmed with second HCG determination on 16 days after ET and transvaginal ultrasound scan was scheduled 2 weeks later to detect the gestational sac of pregnancy.
This study has shown no statistical difference with respect to chemical pregnancy and clinical pregnancy between three groups.
None of the individual PCBs or PCB groupings were associated with
chemical pregnancy or spontaneous abortion.
No statistically significant associations between PCBs and
chemical pregnancy or spontaneous abortion were found.
Increasing quartiles of PCB-153 and the sum of all measured PCB congeners were associated with significantly elevated dose-dependent odds of failed implantation, but no statistically significant associations were observed between PCBs and
chemical pregnancy or spontaneous abortion.