Inflammation of the conjunctiva. It may be acute, subacute or chronic. It may be due to an allergy, an infection (e.g.
Staphylococcus,
Streptococcus, Haemophilus, etc.), a virus inflammation, an irritant (dust, wind, chemical fumes, ultraviolet radiation or contact lenses), or as a complication of gonorrhoea, syphilis, influenzae, hay fever, measles, etc. Conjunctivitis is characterized by various signs and symptoms, which may include conjunctival injection, oedema, small follicles or papillae, secretions (purulent, mucopurulent, membranous, pseudomembranous or catarrhal), pain, itching, grittiness and blepharospasm. The most common type of conjunctivitis is that due to a bacterium and in many cases is self-limiting and subsides without treatment. Treatment of that type includes irrigation of the lid and the use of topical antibiotics.
See conjunctival concretions;
herpes zoster ophthalmicus;
conjunctival injection;
mycophthalmia;
ophthalmia neonatorum;
Stevens-Johnson syndrome;
trachoma.
actinic conjunctivitis See actinic keratoconjunctivitis.
acute conjunctivitis Conjunctivitis characterized by an onset of hyperaemia (most intense near the fornices), purulent or mucopurulent discharge and symptoms of irritation, grittiness and sticking together of the eyelids on waking. In severe cases there will be chemosis, eyelid oedema, subconjunctival haemorrhages and photophobia. The bacterial type is caused by
Staphylococcus epidermidis,
Staph. aureus,
Haemophilus influenzae (
H. aegyptius, Koch-Weeks bacillus),
Streptococcus pneumoniae (pneumococcus). A rare form of acute conjunctivitis is caused by the
Neisseria species (gonococcus, meningococcus, e.g.
gonococcal conjunctivitis), which produce a more severe form of the disease referred to as
hyperacute bacterial conjunctivitis or
acute purulent conjunctivitis. These require immediate treatment with systemic and topical antibiotics. Acute conjunctivitis is also caused by viruses (
viral conjunctivitis), such as herpes simplex or adenoviruses. All forms of acute conjunctivitis occasionally spread to the cornea.
Bacterial conjunctivitis often resolves without treatment within two weeks. Management consists of topical antibiotic therapy (e.g. chloramphenicol, erythromycin) and cold compresses to relieve symptoms.
Acute allergic conjunctivitis most typically resolves spontaneously, otherwise treatment includes sodium cromoglicate.
Acute viral conjunctivitis caused by herpes simplex is treated with antiviral agents (e.g. acyclovir), although viral conjunctivitis caused by other viruses does not respond well to any drug therapy. Supportive treatment such as cold compresses relieves symptoms.
acute haemorrhagic conjunctivitis A highly contagious viral infection of the anterior segment resulting in haemorrhage of the bulbar conjunctiva. The infection is caused by a picornavirus, often associated with pre-auricular adenopathy and a follicular conjunctivitis. The infection is self-limited and lasts 7-10 days. No specific treatment is presently available.
adult inclusion conjunctivitis An acute conjunctivitis caused by the serotypes D to K of
Chlamydia trachomatis and typically occurring in sexually active adults in whom the genitourinary tract is infected. Signs in the eye usually appear one week following sexual exposure. It may also occur after using contaminated eye cosmetics or soon after having been in a public swimming pool, or in newborn infants (called
neonatal inclusion conjunctivitis or
neonatal chlamydial conjunctivitis), which is transmitted from the mother during delivery and appears some 5 to 14 days after birth. The conjunctivitis is mucopurulent with follicles in the fornices, which often spread to the limbal region. The condition is commonly associated with punctate epithelial keratitis, preauricular lymphadenopathy, marginal infiltrates and, in long-standing infection, micropannus in the superior corneal region may also appear. Differentiation from viral follicular conjunctivitis is made through culture, serological and cytological studies. Treatment consists of using both systemic and topical tetracyclines, although in pregnant or lactating women erythromycin is preferable.
Syn. trachoma-inclusion conjunctivitis (TRIC).
See conjunctival follicle;
punctate epithelial keratitis;
lymphadenopathy;
ophthalmia neonatorum;
trachoma.
allergic conjunctivitis Conjunctivitis which is due to a type 1 hypersensitivity reaction to allergens. Common allergens are pollens associated with hay fever, grass (seasonal
allergic conjunctivitis) and air pollutants, house dust mites, smoke (
perennial allergic conjunctivitis). It is characterized by hyperaemia, itching, burning, swelling, tearing, discharge and small papillae. Conjunctival scrapings contain a large number of eosinophils and serum IgE is elevated. The condition is commonly associated with rhinitis (
allergic rhinoconjunctivitis) in which there is also sneezing and nasal discharge. Treatment commonly includes decongestants, oral antihistamines, mast cell stabilizers (e.g. lodoxamine, sodium cromoglicate) and if severe, topical corticosteroid eyedrops.
See vernal conjunctivitis;
decongestants;
hypersensitivity.
angular conjunctivitis Subacute bilateral inflammation of the conjunctiva due to the diplobacillus of Morax-Axenfeld. It involves the conjunctiva in the region of the canthi.
bacterial conjunctivitis See acute conjunctivitis.
catarrhal conjunctivitis Type of conjunctivitis associated with the common cold or catarrhal irritation. It can appear in the acute or chronic form.
contagious conjunctivitis Acute conjunctivitis caused by Koch-Weeks bacillus, adenovirus types 3, 7 or 8 and 19, or a pneumococcus infection. It may be transmitted by respiratory or ocular infections, contaminated towels or equipment (e.g. tonometer heads). It is characterized by acute onset, redness, tearing, discomfort and photophobia. The condition is often self-limiting but keratitis is a common complication.
Syn. epidemic conjunctivitis; epidemic keratoconjunctivitis; pink eye (colloquial).
eczematous conjunctivitis See phlyctenular conjunctivitis.
egyptian conjunctivitis See trachoma.
epidemic conjunctivitis See contagious conjunctivitis.
flash conjunctivitis Conjunctivitis due to exposure to an electric arc, as from a welder's torch.
follicular conjunctivitis Conjunctivitis characterized by follicles (usually in one eye only) caused by adenoviruses or chemical or toxic irritation and frequently associated with lymph-adenopathy.
See adult inclusion conjunctivitis;
conjunctival follicle;
lymphadenopathy.
fungal conjunctivitis See mycophthalmia.
giant papillary conjunctivitis (GPC) Conjunctivitis, characterized by the appearance of 'cobblestones' (large papillae of 0.5 mm or more) on the tarsal conjunctiva of the upper eyelid (and sometimes the lower eyelid). Symptoms include itching, discomfort, mucous discharge and poor vision due to the presence of mucus. The condition may be induced by contact lens wear, ocular prosthesis, or exposed sutures following surgery. This conjunctivitis closely resembles vernal conjunctivitis and is also believed to be an allergic condition. In its early stages as a contact lens-induced condition, it is often referred to as
contact lens papillary conjunctivitis or
contact lens associated papillary conjunctivitis (CLPC, CLAPC). In these cases the regular use of surfactant and protein removal tablets as well as frequent lens replacement reduce the incidence of this condition, which is less prevalent with the wear of rigid gas permeable than soft contact lenses. Management may also include mast cell stabilizers (e.g. sodium cromoglicate) or antihistamine (e.g. levocabastine) and cessation of lens wear.
See vernal conjunctivitis;
contact lens deposits;
enzyme;
surfactant.
gonococcal conjunctivitis See acute conjunctivitis.
granular conjunctivitis See trachoma.
lacrimal conjunctivitis Chronic conjunctivitis caused by an infection of the lacrimal passages.
See lacrimal apparatus.
ligneous conjunctivitis A rare, chronic conjunctivitis characterized by the formation of a firm, whitish membrane or pseudomembrane on the tarsal conjunctiva, usually of the upper eyelid. It is typically bilateral, begins in childhood although it may present in patients up to age 85, is more common in females than in males and may persist for months or years. Its cause is unknown but the predisposing factors include bacterial and viral infections, trauma, hypersensitivity reactions and increased vascular permeability, and it is often associated with inflammations of other mucous membranes. The most effective treatment is surgical excision followed by topical cyclosporine drops, but the condition has a tendency to recur.
See pseudomembranous conjunctivitis.
membranous conjunctivitis See pseudomembranous conjunctivitis.
neonatal conjunctivitis See ophthalmia neonatorum.
phlyctenular conjunctivitis See phlyctenular keratoconjunctivitis.
pseudomembranous conjunctivitis A non-specific inflammatory reaction characterized by the formation on the conjunctiva of a coagulated fibrinous plaque consisting of inflammatory cells and an exudate containing mucus and proteins. This plaque forms either a membrane or a pseudomembrane. The latter is loosely adherent to the conjunctival epithelium and can be peeled off without bleeding or damage to the underlying epithelium. A true membrane, on the other hand, usually occurs with intense inflammation (
membranous conjunctivitis). In this case the conjunctival epithelium becomes necrotic and adheres firmly to the overlying membrane which when peeled leaves a raw, bleeding surface. The cause of either condition may be an infection, of which the common sources are herpes simplex virus, adenovirus, beta-haemolytic
Streptococcus,
Neisseria gonorrhoeae or as a result of the Stevens-Johnson syndrome, ligneous conjunctivitis, ocular cicatricial pemphigoid, atopic keratoconjunctivitis, chemical burns (especially alkali burns), radiation injury or post-surgical complications.
sun lamp conjunctivitis See actinic keratoconjunctivitis.
swimming pool conjunctivitis See adult inclusion conjunctivitis.
vernal conjunctivitis Chronic, bilateral conjunctivitis which recurs in the spring and summer and is more often seen in boys than girls. Its origin is probably due to an allergy. It is characterized by hard flattened papillae of a bluish-white colour separated by furrows and having the appearance of 'cobblestones' located in the upper palpebral portion of the conjunctiva with mucus deposition between the papillae. A second type of vernal conjunctivitis exists which affects the limbal region of the bulbar conjunctiva, characterized by the formation of small, gelatinous white dots called
Trantas' dots or
Horner-Trantas' dots. The chief symptom of the disease is intense itching. Treatment consists mainly of cold compresses and limited (because of side effects) use of topical corticosteroids (e.g. dexamethasone, prednisolone). Sodium cromoglicate or lodoxamide have also been found to be very successful in treating this condition and with fewer side effects than corticosteroids.
Syn. vernal keratoconjunctivitis (VKC) (although this is not strictly speaking a synonym since the condition often involves the cornea; spring catarrh; vernal catarrh (Fig. C14).
See antihistamine;
atopic keratoconjunctivitis;
mast cell stabilizers.
viral conjunctivitis Conjunctivitis caused by a virus. A variety of viruses can produce the disease.
See acute conjunctivitis.


Fig. C14 'Cobblestones' papillae in severe vernal conjunctivitis